Journal of Complementary and Alternative Medical Research 2020-04-04T16:50:07+00:00 Journal of Complementary and Alternative Medical Research Open Journal Systems <p style="text-align: justify;"><strong>Journal of Complementary and Alternative Medical Research (ISSN: 2456-6276)</strong> aims to publish high quality papers (<a href="/index.php/JOCAMR/general-guideline-for-authors">Click here for Types of paper</a>) in the areas of Complementary, Alternative and Integrative medical research. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> Amelioration of Extra-articular Effects Associated with Rheumatoid Arthritis Using Anti-arthritic Herbal Formulations 2020-04-02T12:30:07+00:00 Kemzi N. Elechi-Amadi Ojoye N. Briggs Boma H. Opusunju Ebirien-Agana S. Bartimaeus Edna O. Nwachuku <p><strong>Aim:</strong> This study investigated the ability of some herbal formulations to ameliorate extra-articular effects of some herbal formulations used in the management of rheumatoid arthritis in Nigeria.</p> <p><strong>Methodology:</strong> Forty-nine (49) female albino Wistar rats were used for this study. They were divided into seven groups: A, B, C, D, E, F and G of seven rats each, with Group A serving as negative control while Group B was a positive control. Groups B, C, D, E, F and G were induced with rheumatoid arthritis by injecting 0.1 ml of Complete Freund's Adjuvant into the right hind paw of each rat. The rats were treated with the standard drug and herbal formulations respectively for 28 days as follows: Group C (treated with a standard drug, Celebrex), Group D (treated with the herbal drug, Jointeez), Group E (treated with a herbal drug, Arthropower), Group F (treated with combination therapy of Jointeez and Celebrex) and Group G (treated with combination therapy of Arthropower and Celebrex). At the end of the 28-day treatment period, the rats were anaesthetized with chloroform and sacrificed through puncture of the jugular vein. Five millilitres (5 ml) of blood samples were put into plain bottles for the analysis of biochemical parameters and 3 ml into K3EDTA bottles for haematological analysis. The lipid parameters were analysed using Mindray autoanalyzer while haematological parameters were determined using Sysmex haematology auto analyzer.</p> <p><strong>Results:</strong> Total cholesterol (p&lt;0.001), HDL (p=0.005) and LDL (p=0.004) were significantly reduced in the treated rats compared to the positive control group. Conversely, Packed Cell Volume (p&lt;0.001) and Haemoglobin levels (p&lt;0.001) were significantly reduced in the positive control rats compared to the treated rats. However, Total WBC count was significantly higher in the positive control rats than in the treated rats (p=0.001). The combination therapies used in this study did not offer a significantly different therapeutic advantage over the monotherapies used. The herbal formulations gave therapeutic effects on the extra-articular effects similar to that obtained from the orthodox drug used in this study.&nbsp;</p> <p><strong>Conclusion:</strong> The herbal formulations can be used as alternative regimens for rheumatoid arthritis. It is recommended that herbal formulations be considered for integration into our healthcare system for the management of rheumatoid arthritis.</p> 2020-04-02T00:00:00+00:00 ##submission.copyrightStatement## Hepatoprotective Potential of Hura crepitans L.: A Review of Ethnomedical, Phytochemical and Pharmacological Studies 2020-04-04T16:50:07+00:00 Oluwole S. Owojuyigbe Caleb K. Firempong Christopher Larbie Gustav Komlaga Benjamin O. Emikpe <p>Herbal medicines are the main source of treatment of diseases in non-urban centres of the developing world. Secondary metabolites obtained from herbal sources contain bioactive phytochemicals, many of which have been the origin for the development of novel pharmaceutical drugs. <em>Hura crepitans</em> L. (Euphorbiaceae) or sandbox tree has been beneficial in many ethnomedicinal applications as a purgative, emetic, hepatoprotective, anti-inflammatory, antimicrobial and the treatment of leprosy. Toxicological, phytochemical and bactericidal studies have also been documented. This paper reviews the potential of the <em>Hura crepitans</em> plant in protecting the liver against drug-induced toxicity. The paper dwells extensively on the ethnomedical, phytochemical and pharmacological properties of the plant. In achieving the above, intensive analyses of books and published peer-reviewed journal articles were carried out using credible scientific databases. Four main phytochemicals were revealed to be contained in <em>Hura crepitans</em> stem-bark. Their protective effects were enunciated using animal models. However much more biochemical studies need to be done to establish the hepatoprotective potentials of the various parts and various phytochemicals of <em>Hura crepitans</em> with the need for more preclinical and clinical studies. We, therefore, present in this paper efforts to elucidate and bring to the fore the therapeutic potentials of <em>Hura crepitans</em> plant.</p> 2020-03-24T00:00:00+00:00 ##submission.copyrightStatement##