Journal of Complementary and Alternative Medical Research 2020-06-06T11:40:58+00:00 Journal of Complementary and Alternative Medical Research Open Journal Systems <p style="text-align: justify;"><strong>Journal of Complementary and Alternative Medical Research (ISSN: 2456-6276)</strong> aims to publish high quality papers (<a href="/index.php/JOCAMR/general-guideline-for-authors">Click here for Types of paper</a>) in the areas of Complementary, Alternative and Integrative medical research. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> Ameliorative Effects of Ascorbic Acid and Allium sativum (Garlic) Ethanol Extract on Renal Parenchyma of Gentamicin-induced Nephropathic Rats 2020-06-05T19:32:30+00:00 Dayo Rotimi Omotoso Joy Motunrayo Olajumoke <p>To assess ameliorative effects of Ascorbic acid (AA) and <em>Allium sativum </em>ethanol extract (ASEE) on renal parenchyma of gentamicin-induced nephropathic rats.</p> <p>Thirty Wistar rats (weighing between 180-205 g) were randomly divided into five groups (A-E).&nbsp; These include Group A administered with 0.9% Normal Saline (0.5 ml/kg body weight (b.w.)), Group B administered with gentamicin (GM, 200 mg/kg b.w.) intraperitoneally (i.p.), Group C administered with GM (200 mg/kg b.w.) i.p. and AA (200 mg/kg b.w.) orally, Group D administered with GM (200 mg/kg b.w.) i.p. and ASEE (200 mg/kg b.w.) orally and Group E administered with GM (200 mg/kg b.w.) i.p. and AA (200 mg/kg b.w.) orally and ASEE (200 mg/kg b.w.) orally. All administrations were done once daily for a period of ten (10) days. The body weight of study animals was recorded at the beginning and end of study period. After the study period, renal tissue of study animals was harvested, weighed, processed, stained using H &amp; E technique. Stained sections were examined under microscope for histopathological changes within the renal parenchyma and were scored using image-J software.</p> <p>The results of this study showed that exposure to GM results into significant (P &lt; 0.05) reduction in body and renal tissue weight. However, therapeutic exposure to AA and ASEE either as individual or combined treatment regimen culminated into relatively null body and renal tissue weight loss among treatment groups C-E. In addition, exposure to GM precipitates prominent histopathological changes within renal parenchyma of study animals.&nbsp; As observed with body and renal tissue weight changes, treatment with AA and ASEE also comparatively ameliorate GM-induced nephropathy within renal parenchyma of study animals in treatment groups.</p> <p>The findings of this study therefore showed that AA and ASEE exhibit ameliorative effect on the renal parenchyma of gentamicin-induced nephropathic rats either as distinct or combined treatment regimen.</p> 2020-05-28T00:00:00+00:00 ##submission.copyrightStatement## Factors Favoring Non-compliance of Treatment to People Living with HIV/AIDS in General Reference Hospital of Gbadolite, Nord Ubangi, Democratic Republic of the Congo 2020-06-05T19:32:29+00:00 Kohowe Pagerezo Seraphin Gédéon Ngiala Bongo Kumbali Ngambika Guy Koto-te-Nyiwa Ngbolua <p><strong>Background: </strong>ART is one of the important pillars of the fight against AIDS. It restores immunity and reduces the risk of death. Its success lies in its strict compliance while its non-compliance exposes to the risk of resistance and therapeutic failure. The objective of this study was to determine the factors associated with the non-compliance to ART of PLWHA monitored at the General Reference Hospital of Gbadolite.</p> <p><strong>Methodology: </strong>It was an analytical cross-sectional study conducted between December 2017 and January 2018. The compliance was measured from patient reports and by counting the number of tablets remaining from the current month of the survey. Any PLWHA who failed to take their medication at most 2 times during the month preceding the survey or whose number of remaining tablets was greater than the expected number based on the month's consumption was considered non-compliant. In total, 208 participants were selected based on the established selection criteria and several factors which led to the non-compliance of the treatment.</p> <p>Chi-square and logistic regression were used to determine the associations between factors and the non-compliance. All tests were performed at the threshold of ɑ=0.05.</p> <p><strong>Results: </strong>In fact, 280 PLWHA had participated in the survey. The mean age was 38.7± 7.2 years while the prevalence was 51.1%. Following gender, female accounted as non-compliant (65.7%) than male The main reasons for the non-compliance to treatment were as follows: the order of frequency, medication breakdown, lack of food, forgetting, side effects, travel and fasting. Factors associated with the non-compliance were loneliness in marital status (p=0.000; OR=18.6, CI (8.926 - 38.574)), revival church religion (p=0.002; OR=9.2; CI (2.245 - 37.449)), low level of knowledge of ART principles (p=0.005; OR=1.4; CI (1.169 - 2.735)) and lack of knowledge of ART duration (p=0.021; OR=1.7 and CI (1.020 - 2.829)).</p> <p><strong>Conclusion: </strong>The objective of this study was to determine the factors associated with the non-compliance of ART. The factors found in this work were those that had been found at different levels of association by many authors in previous work, namely marital status, religion, low level of knowledge about ART and lack of knowledge of duration of ART.</p> 2020-06-01T00:00:00+00:00 ##submission.copyrightStatement## Chemical Fingerprinting of Nauclea latifolia, an Antidiabetic Plant, Using GC-MS 2020-06-06T11:40:58+00:00 Bob I. A. Mgbeje Caroline Abu <p><strong>Aim: </strong>Earlier studies have established the antidiabetic activity of <em>Nauclea latifolia.</em> The aim of this study was to obtain chemical fingerprints of the ethanolic extracts of <em>Nauclea latifolia</em> leaf using Gas chromatography-Mass spectrometry (GC-MS), in order to assure proper identification of the plant and to evaluate its phytochemical composition using GC-MS. It was also aimed at unravelling the phytochemical constituents responsible for its antidiabetic activities.</p> <p><strong>Methodology:</strong> The phytochemicals in the plant leaves were extracted by cold maceration in ethanol and subjected to GC-MS analysis.</p> <p><strong>Results: </strong>Chromatograms showed 51 peaks of identified phytochemical compounds. The GC-MS analysis also revealed sixteen (16) active antidiabetic phytochemicals namely: Pentanoic acid 4-oxo- ethyl ester, 2-Methoxy-4-vinylphenol, Triethyl citrate, Quinic acid, 3-O-Methyl-d-glucose, 3,7,11,15-tetramethyl-2-hexadecen-1-ol, Phytol, Hexadecanoic acid, 9,12-octadecadienoic acid, 9,12,15-octadecatrienoic acid, Octadecanoic acid, Hexadecanoic acid 2-hydroxy-1-(hydroxymethyl) ethyl ester, Vitamin E, Campesterol, Stigmasterol, Gamma-sitosterol.</p> <p><strong>Conclusion: </strong>The GC-MS profile provides a suitable chemical fingerprint to assure proper identification of the<em> Nauclea latifolia</em> plant. Sixteen (16) active phytochemicals of the plant leaf are known to have antidiabetic activities; these could be used as a basis for standardization of the plant preparations for diabetes therapy.</p> 2020-06-06T00:00:00+00:00 ##submission.copyrightStatement##