Journal of Complementary and Alternative Medical Research <p style="text-align: justify;"><strong>Journal of Complementary and Alternative Medical Research (ISSN: 2456-6276)</strong> aims to publish high quality papers (<a href="/index.php/JOCAMR/general-guideline-for-authors">Click here for Types of paper</a>) in the areas of Complementary, Alternative and Integrative medical research. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> en-US (Journal of Complementary and Alternative Medical Research) (Journal of Complementary and Alternative Medical Research) Sat, 07 Sep 2019 10:36:18 +0000 OJS 60 Medical Acupuncture in Raynaud's Disease: Protocol Development for Conducting Systematic Review and Meta-analysis <p><strong>Background: </strong>Idiopathic Raynaud’s disease is twice common in women than their counterparts, and secondary Raynaud’s disease co-occurs with a variety of medicosurgical conditions. Both diseases are managed by several medications which are invariably associated with various adverse effects.</p> <p><strong>Objective:</strong> This study aimed to describe several standardized SPIRIT and PRISMA steps and items that help in the development of research protocol directed towards systematic review and meta-analysis conduction concerning Raynaud’s phenomenon managed by clinical acupuncture. <strong>Methods and Results:</strong> Statements, guidelines, list of items and processes related to SPIRIT and PRISMA and their extensions and updated versions are ideal methodological tools in framing Raynaud’s disease and acupuncture research protocols for scientifically conducting not only randomized controlled trials but also systematic review and meta-analysis. By extension, these methodological tools could also be applied to develop research protocols for other diseases and nontraditional treatment interventions with some modifications. A total of 53 studies were included in this study protocol.</p> <p><strong>Discussion:</strong> In line with Traditional Chinese Medicine, the pattern of Raynaud’s disease and pros and cons of medical acupuncture should make an important component of discussion, besides the details of included randomized clinical interventions in systematic review and meta-analysis, which are but not limited to treatment effects, their strengths and limitations, quality, heterogeneity and endpoints.</p> <p><strong>Conclusion:</strong> The development of research protocol for conducting systematic review and meta-analysis is an art and while framing the draft researchers must take into account various SPIRIT and PRISMA statements and guidelines and their latest versions applicable to various diseases including Raynaud’s phenomenon managed by traditional and modern medications across the world.</p> Naseem Akhtar Qureshi, Nasreen Khawer Salahuddin ##submission.copyrightStatement## Sat, 14 Sep 2019 00:00:00 +0000 Randomised Controlled Trial of Salt Solution (Sodium Chloride) Mouth Wash vs Thymol Glycerine Usage in Sore Throat with Non Bacterial Pharyngitis <p><strong>Backgrounds: </strong>Sore throat is one of the most common reasons for visits to the hospital. While most patients with sore throat have an infectious cause (pharyngitis), either bacterial or viral infection, fewer than 20 per cent have a clear indication for antibiotic therapy.</p> <p><strong>Objective:</strong> The aim of this study is to investigate the patient’s clinical outcome after using a salt solution (sodium chloride) and thymol glycerine mouth wash in the evaluation of sore throat patient with non bacterial pharyngitis.</p> <p><strong>Methods:</strong> This was a randomized clinical trial, in which 100 patients who had non-bacterial pharyngitis were divided into two groups: those who gargled a salt solution (sodium chloride 3%) and those who gargled a thymol solution. A sore throat questionnaire was filled out 1 week later.</p> <p>Results: Demographically, the results showed that there were significant differences between the two groups with regard to gender. However, there was no significant difference in age of the patients. A significant difference was observed between the two groups in term of sore throat pain scale, difficulty swallowing scale and swollen throat scale. All p-value are &lt;0.001.</p> <p>Conclusion: Gargling a salt solution, a natural, and harmless substance, can reduce the pain and other symptom of sore throat in patients with non-bacterial pharyngitis.</p> Mohd Azreen Ezairy Bin Mohmad Sallih, Mohd Zukiflee Bin Abu Bakar ##submission.copyrightStatement## Sat, 07 Sep 2019 00:00:00 +0000 Antimicrobial Potency and Bioactive Ingredients of Different Extracts of Prosopis africana against Some Selected Human Pathogenic Microbes: An In-vitro Approach <p><strong>Background: </strong>The resistance to conventional drugs by microbes is at alarming rate and poses extra challenges in the field of medical and pharmaceutical industries. This study was aimed to determine the active ingredients and assess the antimicrobial potency of <em>Prosopis africana</em> leave extract using system of different solvents as aqueous, ethylacetate and n-hexane.</p> <p><strong>Methodology: </strong>The plant specimen was collected, identified, prepared and cold macerated using aqueous, ethylacetate and n-hexane as solvent.&nbsp; The resulted crude extracts were further assayed for anti-infective potency; adopting agar well diffusion protocol against some selected human pathogenic isolates viz <em>Streptococcus pyogenes, Klebsiella pneumoniae, Salmonella typhi,</em> Methicillin-Resistant<em> Staphylococcus aureus </em>(MRSA), <em>Pseudomonas aeruginosa </em>and <em>Candida albicans</em>. The Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) were ascertained using the standard protocol of microdilution assay.</p> <p><strong>Results: </strong>The antimicrobial screening of the crude extracts showcased that <em>P</em>. <em>africana </em>leave is susceptible against all the tested microbial stains by exhibiting significant degrees of inhibition zone of diameter (0 to 25 mm). The positive controls likewise were observed to be vulnerable to the tested isolates while <em>P. aeruginosa </em>was resistant. The MIC was observed at 50.0 to 12.5 mg/mL and MBC at 50.0 mg/mL against some bacteria strains. <em>P. aeruginosa </em>and <em>C. albicans</em> has no bactericidal and fungicidal properties. The phytochemical analysis led to the isolation of anthraquinones, carbohydrates, saponins, terpenes, steroids and cardiac glycosides as the active constituents of the plant part.</p> <p><strong>Conclusion:</strong> This finding provides a logical justification to the traditional healers for the utilization of the plant in the management of different ailments caused by the tested microbes.</p> A. R. Abdulmumin, Z. J. Kassim, I. L. Muhammad, S. B. Mohammed, Y. Ya’aba ##submission.copyrightStatement## Sat, 14 Sep 2019 00:00:00 +0000