Main Article Content
Backgrounds: Sore throat is one of the most common reasons for visits to the hospital. While most patients with sore throat have an infectious cause (pharyngitis), either bacterial or viral infection, fewer than 20 per cent have a clear indication for antibiotic therapy.
Objective: The aim of this study is to investigate the patient’s clinical outcome after using a salt solution (sodium chloride) and thymol glycerine mouth wash in the evaluation of sore throat patient with non bacterial pharyngitis.
Methods: This was a randomized clinical trial, in which 100 patients who had non-bacterial pharyngitis were divided into two groups: those who gargled a salt solution (sodium chloride 3%) and those who gargled a thymol solution. A sore throat questionnaire was filled out 1 week later.
Results: Demographically, the results showed that there were significant differences between the two groups with regard to gender. However, there was no significant difference in age of the patients. A significant difference was observed between the two groups in term of sore throat pain scale, difficulty swallowing scale and swollen throat scale. All p-value are <0.001.
Conclusion: Gargling a salt solution, a natural, and harmless substance, can reduce the pain and other symptom of sore throat in patients with non-bacterial pharyngitis.
Mihara R, Komasawa N, Minami T. Comparison of polyvinyl chloride and tin stylets for postoperative sore throat and hoarseness: A randomised trial. European Journal of Anaesthesiology (EJA). 2017; 34(10):702-703.
Gerber MA. Diagnosis of group A streptococcal pharyngitis. Pediatr Ann. 1998;27:269–73.
Middleton DB. Pharyngitis. Prim Care. 1996;23:719–39.
Ebell MH, Smith MA, Barry HC, Ives K, Carey M. The rational clinical examination. Does this patient have strep throat?. JAMA. 2000;284:2912–8.
Perkins A. An approach to diagnosing the acute sore throat. Am Fam Physician. 1997;55:131–8,141–2.
Middleton DB. An approach to pediatric upper respiratory infections. Am Fam Physician. 1991;44(Suppl. 5):33S–40S, 46S–47S.
Bihani SN, Damle SG. Evaluation of an alum containing mouthrinse on plaque and gingivitis inhibition over 2 weeks of supervised use. Journal of Indian society of Pedodontics and Preventive Dentistry. 1997;15(1):34–8.
Rupesh S, Winnier JJ, Nayak UA, Rao AP, Reddy NV. Comparative evaluation of the effects of an alum-containing mouthrinse and a saturated saline rinse on the salivary levels of Streptococcus mutans. J Indian Soc Pedod Prev Dent. 2010;28(3):138–44.
Palm J, Fuchs K, Stammer H, Schumacher‐Stimpfl A, Milde J, DoriPha investigators. Efficacy and safety of a triple active sore throat lozenge in the treatment of patients with acute pharyngitis: Results of a multi‐centre, randomised, placebo‐controlled, double‐blind, parallel‐group trial (DoriPha). International Journal Of Clinical Practice. 2018;72(12): e13272.
Aljerf L. Syrian medical legislation impacts stories o n pharmacy in the millennium. Chronicles of Pharmaceutical Science. 2017;1(5):307-311.
Huynh NC-N, Everts V, Leethanakul C, Pavasant P, Ampornaramveth RS. Rinsing with Saline Promotes Human Gingival Fibroblast Wound Healing In vitro. PLoS ONE. 2016;11(7):e0159843.
Zhang Z, Avraham H, Cohen DM. Urea and NaCl differentially regulate FAK and RAFTK/PYK2 in mIMCD3 renal medullary cells. Am J Physiol. 1998;275(3Pt 2): F447–51.
Lunn JA, Rozengurt E. Hyperosmotic stress induces rapid focal adhesion kinase phosphorylation at tyrosines 397 and 577. Role of Src family kinases and Rho family GTPases. The Journal of biological chemistry. 2004;279(43):45266–78.
Burg MB, Ferraris JD, Dmitrieva NI. Cellular response to hyperosmotic stresses. Physiological reviews. 2007;87 (4):1441–74.
Lim JK, Saliba L, Smith MJ, McTavish J, Raine C, Curtin P. Normal saline wound dressing—is it really normal? Br J Plast Surg. 2000;53(1):42–5.
Gannon R. Wound cleansing: sterile water or saline? Nursing Times. 2007;103(9):44–6.