Anti-Inflammatory Activity of Ethanol Leaf Extract of Arthropteris Orientalis in Wistar Albino Rat

Akhigbe Faith Omoighele

Department of Pharmacology and Therapeutics, University of Nigeria, Enugu, Nigeria.

Ckikere A. Anusiem

Department of Pharmacology and Therapeutics, University of Nigeria, Enugu, Nigeria.

Samuel I. Ghasi

Department of Pharmacology and Therapeutics, University of Nigeria, Enugu, Nigeria.

Ajirioghene E. Akpotu *

Department of Pharmacology, PAMO University of Medical Sciences, Port-Harcourt, Rivers State, Nigeria.

Chidi E. Ezerioha

Department of Pharmacology, University of Port Harcourt Rivers State, Nigeria.

Funso-Babarimisa, Funso

Department of Pharmacology Kogi State University, Anyigba, Nigeria.

*Author to whom correspondence should be addressed.


The study investigated the anti-inflammatory activity of ethanol leaf extract of Arthropteris orientalis in wistar albino rat. The plant extract was obtained with the procedure as described by Khalifa et al. [1] and both acute and chronic anti-inflammatory properties was assessed. Five groups of five animals each were utilized for acute and chronic inflammation respectively. Anti-inflammatory effect of the extract was evaluated on egg albumin induced paw edema in albino rats and edema induced by formalin in the wistar albino rats’ paw for acute and chronic inflammation respectively. The extract had 26.665% tannin while flavonoid, saponin, phenol, and glycoside had 0.784%, 0.631%, 0.183% and 0.057% respectively. The result revealed that the extract at 500 mg/kg exhibited significant inhibition (p<0.05) of systemic acute paw edema at the 4th hour of the second phase of edema in comparison with the standard drug. The results reveal that intraperitoneal administration of ethanol leaf extract of Arthropteris orientalis on formalin-Induced paw edema in wistar albino rats at (100 and 500mg/kg) and (100mg/kg) exhibited significant inhibition (p<0.05) in mean paw volumes on day 1 and 2 respectively. The extract did not produce any significant hematological change. These results show that Arthropteris orientalis has potential anti-inflammatory properties.

Keywords: Anti-inflammatory, Arthropteris orientalis, Formalin, Hematology

How to Cite

Omoighele, Akhigbe Faith, Ckikere A. Anusiem, Samuel I. Ghasi, Ajirioghene E. Akpotu, Chidi E. Ezerioha, and Funso-Babarimisa, Funso. 2023. “Anti-Inflammatory Activity of Ethanol Leaf Extract of Arthropteris Orientalis in Wistar Albino Rat”. Journal of Complementary and Alternative Medical Research 24 (3):35-45.


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