Investigation Effect of Aloe Vera in Fresh Gel Form on Rabbit’s Model Wound
Nabhan AL-Dhamary
Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a City, Yemen.
Adnan Al-Adhal
Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a City, Yemen.
Hussein Kadi
Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a City, Yemen.
Mohammed Amood AL-Kamarany *
b Department of Pharmacy Practice, Faculty of Clinical Pharmacy, Hodeidah University, P.O. Box 3114, Hodeidah City, Yemen.
*Author to whom correspondence should be addressed.
Abstract
Background: Aloe is plant possessing a great therapeutic potential in folk medicine in Yemen namely Aloe vera used as a multipurpose skin treatment.
Objective: Therefore, this study aimed to investigate the effect of topical Aloe vera gel in fresh form on the wound healing of rabbit model in comparison with Moist Exposed Wound Ointment (MEBO) .
Methods: The experimental animals as models of excision wounds that were classified into four groups. The 1st group was not treated as a control, the 2nd group was treated with a placebo (petroleum gel), the 3rd group was treated with Mebo as drug standard, and the 4th group was treated with Aloe vera gel in fresh form. This study was carried out in Sana’a city during the period of three weeks. The healing parameters were epithelization period (scar fall day) and percentage of wound contraction (%) and the data obtained were analyzed.
Results: The results showed that the significant difference between study group (p < 0.05) and the effect of this plant on an increase in the percentage (%) of wound contraction was better than the standard drug (Mebo) group and other groups. On the other mean, on the 16th day, the percentage of wound contraction of the treated group with Aloe vera was 100 % while in the treated group with Mebo was 97.6%. In addition, in placebo and control groups were 76.6 % and 73.8 %, respectively.
Conclusion: Finally, from these findings, it could be concluded that the application of Aloe vera gel in topically administered to an open wound induces significant wound contraction and accelerates wound healing and this herbal may be a promising medication for open wounds.
Keywords: Aloe vera, wound, anti-inflammatory effect, therapeutic potential
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