https://journaljocamr.com/index.php/JOCAMR/issue/feed 2026-10-18T09:22:58+00:00 Journal of Complementary and Alternative Medical Research [email protected] Open Journal Systems <p style="text-align: justify;"><strong>Journal of Complementary and Alternative Medical Research (ISSN: <a href="https://nsl.niscpr.res.in/ISSNPROCESS/issnassignedinfo.jsp">2456-6276</a>)</strong> aims to publish high quality papers (<a href="https://journaljocamr.com/index.php/JOCAMR/general-guideline-for-authors">Click here for Types of paper</a>) in the areas of Complementary, Alternative and Integrative medical research. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> https://journaljocamr.com/index.php/JOCAMR/article/view/785 2026-10-17T10:37:15+00:00 Abiodun Bukunmi Aborisade [email protected] Olaleye Samuel Aremu Adewale Adetutu

<p>Co-codamol combines paracetamol (acetaminophen) and codeine, but the multisystem effects of repeated exposure to the combined formulation remain insufficiently characterised. This study evaluated the effects of repeated oral co-codamol administration on haematological, hepatic, renal, oxidative, inflammatory and histopathological parameters in adult male Wistar rats and examined predicted interactions of selected constituents with analgesia-associated molecular targets. Twenty rats were randomly allocated to four groups (n = 5). Groups A, B and C received co-codamol at 100, 97 and 90 mg/kg body weight, respectively, while Group D received normal saline. Treatments were administered orally once daily for 28 consecutive days. Repeated co-codamol exposure was associated with alterations in erythrocyte, leucocyte, platelet and red-cell indices. Changes were also observed in serum alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase and alkaline phosphatase activities, together with serum creatinine and urea concentrations. Hepatic and renal malondialdehyde, reduced glutathione, superoxide dismutase and total protein were assessed, with treatment-associated alterations observed in several of these parameters. Hepatic and renal IL-6 and IL-10 concentrations were also altered. Histopathological examination demonstrated treatment-associated changes in liver and kidney tissues. Molecular docking showed favourable predicted interactions between codeine and selected analgesia-associated targets. The measured responses were not uniformly proportional to dose across all endpoints. Overall, repeated co-codamol exposure was associated with multisystem biological alterations under the experimental conditions, while the docking findings provide computational hypotheses that require experimental validation.</p>

2026-10-17T00:00:00+00:00 Copyright (c) 2026 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journaljocamr.com/index.php/JOCAMR/article/view/789 2026-10-18T09:22:58+00:00 Ahmed Tawfik ElOlemy [email protected] Gazzaffi Ibrahim Mahjoup Mohammed Ahmed ElOlemy Saleh Ibrahim AlQasoumi

<p>Background: Cupping therapy is used in athletic settings, although its reported popularity is more readily documented than evidence of its comparative efficacy. Suction-based procedures differ in their invasiveness, and evidence from patients with chronic pain cannot be assumed to apply directly to sports recovery. Objective: To critically examine athlete-specific research on symptom relief, physiological recovery, performance, harms and regulatory considerations, with mechanistic and non-athlete evidence interpreted separately. Methods: A targeted narrative search of peer-reviewed primary studies, systematic reviews and authoritative anti-doping guidance was complemented by citation tracking and verification of bibliographic records; evidence was appraised qualitatively without meta-analysis or a formal certainty-rating exercise. Results: A review of 11 historical athlete trials (498 participants) reported some favourable symptom and biomarker findings, mostly relative to untreated controls, but identified high or unclear risk of bias and no safety reporting. More recent trials showed mixed findings, including a randomised comparison involving 81 recreational runners that found no statistically significant benefit for muscle pain, fatigue, perceived recovery or vertical-jump height compared with sham manual intervention. A sham-controlled study of 40 baseball players found no advantage in objective exercise performance, whereas comparisons in taekwondo, table tennis and runners detected selected short-term subjective, autonomic or sleep outcomes. A 32-runner wet-versus-dry trial found no between-group advantage for measured endurance performance. A separate non-sham within-participant comparison in active men reported sprint-power differences, which cannot establish efficacy against sham treatment. Conclusions: Short-term symptom relief is possible, but evidence for accelerated tissue repair, durable recovery, injury prevention or performance enhancement is insufficient. Adverse-event rates cannot be estimated reliably, and blood-withdrawing wet cupping raises specific safety and 2026 anti-doping concerns.</p>

2026-10-18T00:00:00+00:00 Copyright (c) 2026 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.