Journal of Complementary and Alternative Medical Research <p style="text-align: justify;"><strong>Journal of Complementary and Alternative Medical Research (ISSN: 2456-6276)</strong> aims to publish high quality papers (<a href="/index.php/JOCAMR/general-guideline-for-authors">Click here for Types of paper</a>) in the areas of Complementary, Alternative and Integrative medical research. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> SCIENCEDOMAIN international en-US Journal of Complementary and Alternative Medical Research 2456-6276 Toxicological Effect of Euphorbia heterophylla Linn <p><em>Euphorbia heterophylla </em>has been reported to possess enormous medicinal benefits hence there is a need for holistic research on its toxicological effects. Four different solvents (cold and hot water, chloroform and 80% methanol) were used to extract the aerial parts of <em>Euphorbia heterophylla </em>Linn. Experimental albino rats were obtained from Federal University of Technology Akure’s Microbiology Department Animal House. Toxicological analysis of <em>Euphorbia heterophylla </em>extracts was carried out on the experimental albino rats. The animals were grouped into thirteen with three rats in a group different concentrations of the extracts were administered orally to different groups of the rats for a period of two weeks (14 days). Sterile distilled water was administered to the negative control group. During the 14 days of extracts administration, the animals were observed for clinical manifestations like salivation, nervousness, imitability, itching of the nose and diarrhoea. After the expiration of the two weeks, the animals were sacrificed and vital organs like heart, liver, kidney and intestine were harvested and examined for any degenerative changes and lesions. Blood samples were collected before and after the administration of the extracts to check for blood parameters (Packed Cell Volume (PCV), white blood cell count (total and differential), erythrocyte sedimentation rate (ESR) and haemoglobin (Hb) estimation. The toxicological results of the extracts showed various degrees of abnormalities detected in the histopathological sections of the intestine, kidney and the heart. It was found that all the extracts at different concentrations burnt the intestinal walls of all the animals tested. There were significant reductions in the total white blood cells (WBC) and neutrophil counts while there was a significant increase in the lymphocytes count after the administration of the extracts. The findings of this study revealed that <em>Euphorbia heterophylla </em>had toxicological effects on the albino rats organs but increases there lymphocytes count, boosting their immune system, however advance researches to eliminate the toxic phytochemicals from the extract is recommended.</p> J. K. Kone A. K. Onifade ##submission.copyrightStatement## 2021-01-18 2021-01-18 1 15 10.9734/jocamr/2020/v12i330207 In vitro and In vivo Anticonvulsant Effect of Hydroalcoholic Extract of Moringa stenopetala in Mice Models <p><strong>Background:</strong> Epilepsy is a debilitating neurological disorder that directly affects approximately 65 million people worldwide. In the search of safe and effective antiepileptics traditional treatment practices are one area of research to obtain novel molecules. <em>Moringa stenopetala </em>root is claimed to be used for epilepsy treatment in Konso area, Southern Ethiopia. But there was no scientific research evidence for the claimed use of the plant.</p> <p><strong>Objective:</strong> This study was conducted to explore the anticonvulsant activity of hydro-alcoholic (80% methanol) extract of root of <em>Moringa stenopetala</em>.</p> <p><strong>Methods:</strong> The dry residues of the plant extract was used for the test. <em>In vitro</em> 0Mg<sup>2+</sup> mice model at dose 0.7 mg/kg of extract, diazepam(3μM) and untreated brain slice groups were used to compare the presence of seizure like event (SLE). <em>In vivo</em> pentylenetetrazol (PTZ) model with 85 mg/kg subcutaneously was used to compare the seizure on set time with two extract doses and diazepam 5 mg/kg. The data was presented with mean± standard error. In maximum electric shock (MES) model 54 mA was passed for 0.2 second transauricularly in mice. The mean time of hind limb extension was recorded for doses 400 mg/kg and 800mg/kg of the extract and 10 mg/kg phenytoin. The means were compared for statistical significance using one way ANOVA post hoc LSD whereas proportions were compared using Fishers exact test with P-value &lt; .05.</p> <p><strong>Results:</strong> <em>M. stenopetala </em>extract has shown statistically significant anticonvulsant activity <em>in vitro</em> compared to control (P&lt;.05). A positive control, the known anticonvulsant diazepam (3μM), showed significant anticonvulsant activity (P&lt;.05). <em>In vivo</em> MES model showed statistically significant anti-seizure activity at both doses (P&lt;.05). But the crude extract failed to show statistically significant activity at all doses of PTZ model (P&gt;.05).</p> <p><strong>Conclusion: </strong>The results of this study showed that crude extract of <em>Moringa stenopetala</em> exhibited anti-convulsant effect both <em>in vitro</em> and <em>in vivo</em> MES models.</p> Samson Sahile Salile Teferra Abula ##submission.copyrightStatement## 2021-01-19 2021-01-19 16 23 10.9734/jocamr/2020/v12i330208