Open Access Original Research Article

Validation of Siddha Diagnostic Procedure of Manikkadai nool for Gunmam Patients at Government Siddha Medical College & Hospital, Palayamkottai

Rakulini Raveendran, A. Rajarajeshwari, S. Victoria

Journal of Complementary and Alternative Medical Research, Page 1-11
DOI: 10.9734/jocamr/2019/v8i330121

Introduction: Siddha Medicine is a system of traditional medicine originating in ancient Tamil Nadu in South India and Sri Lanka. Traditionally, it is taught that the siddhas laid the foundation for this system of medicine. Siddha system has a unique diagnostic method to identify the diseases and their causes. Manikkadai Nool is one of the diagnostic tool. It is explained in the Agasthiyar Soodamani Kajiru Soothiram by Saint Veadammamuni in Pathinen Siddhar Naadi Nool.

Aim: The primary aim of this study was to validate the Siddha diagnostic procedure of Manikkadai nool for gunmam patients.

Study Setting: Government Siddha Medical College, Palayamkottai from April to August 2019.

Methodology: It is an observational study. After identifying the eligible subjects, Data will be collected by using the interview administrated questionnaire & relevant data will be collected by measurement. Collected data were processed and statistically analysed by a simple statistical method using Microsoft Excel.

Results and Discussion: Gunmam symptoms are included in 10, 9 ½, 8 ¾, 8, 7 ½, 7, 6 ½ & 6 ¼ Manikkadai measurements according to the siddha literatures. Researcher has been divided the gunmam conditions as mild moderate and severe condition according to the evidence of literatures, Researcher has been included Premonitory symptoms as Mild Condition, Common signs and symptoms as Moderate Condition and complications as Severe condition. Mild condition is in 10-9 fbs Manikkadai measurements. Moderate condition is in 8 ¾-7 ¾ fbs Manikkadai measurements. Severe condition is in 7 ½-6 ½ > Manikkadai measurements. 55% (11) of right hand Manikkadai measurements in male and 53% (16) of Right hand Manikkadai measurements in female have been correlated with the siddha literatures in the diagnosis of gunmam. Pearson correlation value implies that negative correlation between the chronicity of gunmam and Manikkadai measurement. This data showed the negative relationship between the severity of gunmam, & manikkadai measurements.

Conclusion: Majority of the gunmam subjects were females (60%). The maximum number of subjects was observed in Pitha Kaalam. Majority of the gunmam subjects had vali azhal naadi (38%) and azhal vali naadi (32%). Nei kuri was observed as vali azhal & azhal vali in gunmam subjects. Siddha Physicians could be diagnosed the gunmam fifty percentage with the help of Manikkadai measurements. Pearson correlation value implies that negative correlation between the chronicity of gunmam and Manikkadai measurement. This data showed the negative relationship between the severity of gunmam & manikkadai measurements. Out of 50 gunmam subjects, 45 were in the assumed assessment criteria range. So further study is essential to validate this assumed assessment of criteria of manikkadai measurement in diagnosis of gunmam.

Open Access Original Research Article

Effect of Ethanolic Extract of Trigonella foenum-graecum L. Seeds on Reproductive System of Male Albino Rats

Madhulika Singh, G. N. Verma

Journal of Complementary and Alternative Medical Research, Page 1-8
DOI: 10.9734/jocamr/2019/v8i330122

Aims: The present study was undertaken to assess the antispermatogenic and antifertility efficacy of ethanolic extract of Trigonella foenum-greacum seeds.

Methodology: Aqueous solution of the extract (250 mg/kg b.wt/day) when administered orally for 45 days to adult male albino rat (Duckray strain).

Results: Seeds extract caused inhibition of spermatogenesis as well as inability to mate with normal untreated female rats of proven fertility. There occurred a significant decrease in absolute and relative weights of testis and seminal vesicle and increase in epididymal weight, whereas of ventral prostate and coagulating gland remained unchanged. Sperm concentration and motility in the cauda epididymis was also decreased. Increased incidence of separation of head and tail pieces of spermatozoa was seen in the epididymal smear. Histologically, testis of experimental animals showed arrest of spermatogenesis at the secondary spermatocytes stage and there was deposition of cellular debris in semineferous tubular lumen. The spermatids were not properly developed and interstitial cells were very sparse and degenerated. However, there was no evidence of damage to the spermatogonia. Oral treatment of extract did not affect the body weight of animals. Quantitative estimation of marker testicular enzymes, e.g., sorbitol dehydrogenase showed a significant decrease whereas lactate dehydrogenase and gamma-glutamyl transpeptidase levels were significantly increased.

In conclusion: These results suggest that T. foenum-greacum, may induce male infertility in rats, therefore, should be considered further as a potential male antifertility agent.

Open Access Original Research Article

A Comparative Analytical Study on Two Types of Sharibadi Decoctions: An Ayurveda Preparation

R. D. H. Kulathunga, E. D. T. P. Gunarathna, N. D. N. Jayawardhana, R. H. S. K. De Silva, R. L. D. S. Ranasinghe, M. H. Faisulhaq, U. K. A. Samarasinha, L. D. A. M. Arawwawala

Journal of Complementary and Alternative Medical Research, Page 1-8
DOI: 10.9734/jocamr/2019/v8i330123

Aim: The present study aimed to compare the Sharibadi decoction which was prepared in two different ways. Sharibadi decoction A: All the ingredients are available including a local variety of H. indicus and Indian variety of H. indicus. Sharibadi decoction B: All the ingredients are available except the local variety of H. indicus and double the amount of Indian variety of H. indicus.

Methodology: Phytochemical (in terms of secondary metabolites and Thin Layer Fingerprint profiles) and Physico-chemical (in terms of ash values and extractable matter) analyses were carried out to compare the Sharibadi decoction A with the Sharibadi decoction B.

Results: Comparison of phytochemicals and Thin Layer Fingerprint profile of Sharibadi decoction A with that of Sharibadi decoction B revealed the differences in phytochemical compound/s presence in both decoctions. However, Physico-chemical parameters of Sharibadi decoction A were almost similar to that of Sharibadi decoction B.

Conclusion: Absence of local variety of H. indicus gives an impact on phytochemical constituents rather than Physico-chemical parameters of Sharibadi decoction. However, phytochemicals play a major role when a drug exhibits its therapeutic effect/s. Therefore, to get the best therapeutic effect of Sharibadi decoction, both local variety of H. indicus and Indian variety of H. indicus should be used with other ingredients.

Open Access Original Research Article

Evaluation of Sub-acute and Sub Chronic Toxicity Profile of the Aqueous Leaf Crude Extract of Melanthera Scandens (Schumach & Thonn) in Wistar Rats

Daniel Chans Mwandah, Ibrahim Ntulume, Adamu Almustapha Aliero, Kennedy Kiyimba, Emmanuel Tiyo Ayikobua, Richard Bwanika, Martin Odoki, Eliah Kwezira, Richard Maseruka, John Odda, Joseph Oloro

Journal of Complementary and Alternative Medical Research, Page 1-16
DOI: 10.9734/jocamr/2019/v8i330124

Aims: Although Melanthera scandens is a plant widely used in traditional medicine for the management of seizures, stomach ulcers and sores, dysmenorrhea, diabetes and malaria, there was scanty information about its safety. There was, therefore, a need to evaluate the sub-acute and subchronic toxicity studies of this plant which would reflect on its safety.

Methodology: This was an experimental laboratory study. The research was conducted at Kampala International University-Western Campus at the Pharmacology laboratory from February to June 2017. The sub-acute toxicity was evaluated after administering daily oral doses of M. scandens crude extract (250, 500 and 1000 mg/kg) for 28 days and 90 days for subchronic study, after which the effect on haematological, biochemical and histopathological parameters were assessed in male and female Wistar rats (five of each sex).

Results: Sub-acute toxicity results revealed that there was a significant decrease in the AST between the male Wistar rats that received 250 mg/kg (P= .005) and those that received 500 mg/kg (P= .05) as compared with the control group. Subchronic studies showed a significant increase in ALP (P= .05) at 1000 mg/kg compared with 500 mg/kg. Terminal necropsy did not reveal any treatment-related histopathological findings. There were also no toxicologically significant treatment-related effects on haematological parameters. The sub-acute toxicity results suggest that doses of 250mg/kg and 500mg/kg are safe and could be hepatoprotective due to reduced levels of AST and ALP, while the subchronic toxicity study results suggest that doses greater than 1000 mg/kg could be toxic to the plasma membrane, liver cells or endoplasmic reticulum due to increased ALP levels at this dose.

Conclusion: The M. scandens crude extract did not cause significant toxicity on haematological and histopathological indices, after sub-acute and subchronic administration in Wistar rats.

Open Access Original Research Article

Scope of Ayurvedic Medicine in Pneumonia Patients Visiting Govt. Hospitals in Bangladesh: A Cross-sectional Study

Nazmul Hasan, Shurab Hossain, M. Atiqul Haque

Journal of Complementary and Alternative Medical Research, Page 1-6
DOI: 10.9734/jocamr/2019/v8i330125

Ayurveda is considered by many scholars to be the oldest healing science and is often called the ‘Mother of all healing’. In this sub-continent, it is one of the ancient health care systems. Nowadays, it is practiced by millions of people in India, Nepal, Sri Lanka, China, Tibet, Pakistan, and Bangladesh. In response to the urge of public demand and to achieve the goals of primary health care, the Government of Bangladesh has appointed and posted numbers of Ayurvedic doctors all over Bangladesh. It was due to assay the impact of these recruitments in primary health care as well as in national health services. Aiming this a cross-sectional study was designed to conduct within randomly selected twenty-two centers, approximately covering 35% of each administrative division. This study revealed that roughly 12% of total visiting patients seeking Ayurvedic health service, and among them 7.26% of patients were <5 years old children. A calculative 14.20%, children were suffering from Respiratory Tract Infection (RTI), and of these RTI patients, 42.77% were diagnosed as pneumonia. Bashakarist, Chandramrita rasa, Shwas Kuthar rasa, and Talishadi Churna were prescribed invariably to manage RTIs and pneumonia. This study revealed with such limited manpower of Ayurvedic medical service, it is helping significantly in securing primary health care goals set by the government. The inclusion of more qualified manpower and engaging them in effective training may help the government to conquer the zenith of success in national health services.