Open Access Case Report

Tumor Therapy with Amanita phalloides: Benefits and Limitation

Isolde Riede

Journal of Complementary and Alternative Medical Research, Page 29-37
DOI: 10.9734/jocamr/2021/v13i130217

Background: Classical tumor treatments can fail: surgeries, radiation and chemotherapy not always elongate the life span. Less destructive treatments are possible nowadays. To find and analyse the efficiency of alternate treatments, long term case reports are essential.

Aim: To determine long term analyses of Amanita treatment in patients with different tumor types.

Methods: Patients are treated with Amanita alone, as long as the tumor growth of cells can be retarded. Other anti tumor therapies are applied in addition, when the retardation of the tumor growth is not sufficiently manageable with Amanita alone. The treatments with Amanita are supported by application of Terebinthina laricina in intervals to eliminate Borrelia.

Results: The state of a patient with a thyroid-carcinoma and a rectum-carcinoma can be stabilized for ten years with Amanita alone, until her age of 90 years. The patient cannot further tolerate uptake of Amanita. Thyroid cells start to grow, rectum-carcinoma cells grow slower. The disease state of a patient with prostate-carcinoma can be stabilized with Amanita alone for six years. Other therapies are applied from then on in intervals in addition for further six years. No chemotherapy or radiation is applied. The patient died at the age of 84 with metastases. A patient with B-cell chronic lymphatic leukemia is treated with Amanita as sole antitumor therapy for eleven years. After that period, no further antitumor treatment is necessary, the patient lives now with high but stable leukocyte count for two years after the end of the Amanita therapy.

Conclusions: Amanita can inhibit tumor growth of different tumor types for a long period of time, elongation of the life span is possible. A synergistic effect of anti-Borrelia treatment is observed. Occasionally the tumor growth of cells stops without further anti tumor therapy, and no correlation with the origin can be identified.

Open Access Original Research Article

Blood Electrolyte Levels in Male and Female Pitbull Dogs

L. C. Chuku, N. C. Chinaka, E. Emesiri

Journal of Complementary and Alternative Medical Research, Page 1-7
DOI: 10.9734/jocamr/2021/v13i130213

The study evaluates blood electrolytes in male and female pit bull dogs to ascertain their level of predominance in extracellular fluid. Blood samples were collected, processed and analyzed for electrolyte levels using standard protocol and absorbance reading taken by spectrophotometric method. Post statistical package for social science (SPSS) analysis indicates that mean serum electrolyte levels of male pit bull dogs were 179.2±66.79 mmol/l for sodium, 3.54±0.55 mmol/l for potassium, 43.72±2.72 mmol/l for bicarbonate, chloride was 116±12.81 mmol/l, phosphorus was 4.26±0.61, calcium and magnesium were 1.74±0.50 and 1.48±0.18 mmol/l respectively. The female pit bulls had a mean serum electrolyte level of 157.4±76.07 mmol/l for sodium, 5.12±1.23 mmol/l for potassium, 75.98±27.98 mmol/l for bicarbonate, chloride and phosphorus are 123.5±17.98 mmol/l and 4.06±0.95 mmol/l, calcium and magnesium were 1.56±0.16 and 1.70±0.39 mmol/l respectively. The result implies that serum concentration of sodium, bicarbonate, chloride, phosphorus and magnesium in both male and female pit bull dogs were significantly (p<0.05) higher than normal electrolyte range, while potassium and calcium levels were within range. The electrolyte imbalance could lead to impaired fluid level and electrolyte osmolarity resulting in neurological consequences such as seizure disorders, hypoparathyroidism, metabolic acidosis and alkalosis.

Open Access Original Research Article

Snail Slime: Evaluation of Anti-Inflammatory, Phytochemical and Antioxidant Properties

N. C. Chinaka, L. C. Chuku, G. George, C. Oraezu, G. Umahi, O. F. Orinya

Journal of Complementary and Alternative Medical Research, Page 8-13
DOI: 10.9734/jocamr/2021/v13i130214

Snails posses numerous nutritional, medicinal and therapeutic properties, making it an essential component of human nutrition, medicinal and skin health. This study is aimed at evaluating the anti-inflammatory and antioxidant properties of snail slime obtained from giant African land snail (Achatina fulica). The slime was extracted by low heat method and anti-inflammatory properties was ascertained by inducing paw edema in day old chicks using carrageenan, the phytochemical screening was conducted to ascertain the level of phenols and flavonoids, while the antioxidant properties was determined by DPPH radical scavenging activity, using ascorbic acid as standard. Statistical analysis using ANOVA version 20.0 was conducted to analyze the data obtained from the study. Post study statistics of data (mean ± SD) indicates that the snail slime extract potentially posses anti-inflammatory, relative phytochemical and antioxidant properties at significant (p≤0.05) level, hence validating its use in nutrition, medicinal and cosmetic purposes, and preparations.

Open Access Original Research Article

Proximate and Phytochemical Compositions of Dried Seeds of Fluted Pumpkin (Telfairia occidentalis)

L. C. Chuku, N. C. Chinaka

Journal of Complementary and Alternative Medical Research, Page 14-19
DOI: 10.9734/jocamr/2021/v13i130215

Proximate and phytochemical analyses were carried out on dried fruited pumpkin (Telfaira occidentalis) seeds. Standard experimental procedure and statistical analysis using SPSS version 20.1 were carried out after triplicate evaluation of the sample. Results of the proximate analysis indicated that the dried seeds contains moderate percent of carbohydrate (11.43±0.92%) and fibre (15.71±0.74%), high percentage protein (34.56±1.36%) and lipid (32.50±1.08%), ash (4.40±0.02%) and moisture (1.40±0.01%) contents were low statistically. The qualitative and quantitative phytochemical analysis showed that dried seeds of Telfairia occidentalis possessed very low (statistically insignificant, p>0.05) level of cyanogenic glycoside (0.001±0.01 µg/g) which makes it non toxic and consumable. Tannin (0.488 ± 0.012 µg/g) and oxalate (0.194±0.01 µg/g) where low in percentage, while phylate (3.75±0.018 µg/g) and saponin (4.00±0.02 µg/g) levels were statistically high (p<0.05). The analysis revealed the sample as rich in protein and lipid, with moderate amounts of carbohydrate and fibre. It also indicates absence of cynogenic glycoside and low oxalate level which interfere with mineral absorption in the body. Hence, the seed is a very good protein source especially for patients with protein energy malnutrition (PEM), growing children and diabetic patients due to its rich energy source for body utilization and for extraction of cooking oil due to its high lipid content.

Open Access Original Research Article

Otorhinolaryngological Trauma in Some Private Health Facilities in Benin City

I. O. Akpalaba, F. O. Ogisi, R. O. Momoh

Journal of Complementary and Alternative Medical Research, Page 20-28
DOI: 10.9734/jocamr/2021/v13i130216

Background: Otorhinolaryngological trauma is common in clinical practice. The disaster caused by otorhinolaryngological trauma arises from its morbidity and mortality. This is due to increased cost of care and varying degree of physical, cosmetic and functional disfigurements.

Aim: This study was conducted to determine the causes, mechanisms of trauma and outcomes of these injuries in private setting; and to profer possible preventive measures.

Methods: This study was a one-year descriptive prospective study on patients with otorhinolaryngological trauma managed at three private health settings in Benin City, Nigeria. All consecutive trauma patients seen from May 2016 to April 2017 constituted the sample size. Total population sampling technique was used. Statistical analysis was performed using SPSS version 20.0.

Results: A total of 31 patients were studied. Age ranged from 1 to 80 years. Median age was 35 years. Male to female ratio was 1.1:1. The commonest cause of trauma was use of cotton buds to clean the ears in 48.4% patients.  This was followed by foreign bodies in the ear in 12.9% of the patients. This was not statistically significant as p>0.05. The commonest mechanism of trauma was from Tympanic membrane perforation, canal laceration and ear canal inflammation in 48.4% of patients. The ear was the most affected region in 80.6% of the patients. The greatest complain at presentation was ear discharge in 38.7% of the patients, followed by hearing loss in 35.5% patients. The commonest complication was tympanic membrane perforation noted in 48.4% of the study population followed by chronic suppurative otitis media in 35.5% of them. Majority of the subjects (87.1%) were treated as outpatients. Only 12.9% of the subjects required admission to the ward. The most common treatment modalities used were ‘keeping the ear dry’ protocol, ear toileting and daily ear dressing in 80.6%, 41.9% and 38.7% of the patients respectively. The median length of hospital stay for in-patients was 7 days (range 3 to 11 days). There was no mortality. Majority of the patients (77.4%) had full recovery. Tympanic membrane perforation was persistent in 22.6% of the patients.

Conclusion: Otorhinolaryngological trauma constitutes a significant cause of morbidity in private hospital setting. Majority of these trauma are both preventable and treatable through public enlightenment programmes and early presentation to Otorhinolaryngologists respectively.