Does Oral Administration of Fresh and Dry Ginger (Zingiber officinale) Juice have Effect on the Lipid Profile of Albino Rats
Helen Anthony Waribo *
Department of Medical Laboratory Science, Rivers State University, Nkpolu Oroworukwu, Rivers State, Nigeria.
Emmanuel Chukwu Ani
Department of Medical Laboratory Science, Rivers State University, Nkpolu Oroworukwu, Rivers State, Nigeria.
Atoukaritou Omodi Osuosa
School of Medical Laboratory Science, Rivers State College of Health Science and Management Technology, Oro-Owo Rumueme, Port Harcourt, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Aim: This study compares the effect of fresh and dry ginger juice on the lipid profile of albino rats.
Methodology: Fifteen(15) albino rats with average weight of 150g divided into three groups of five (5) rats each were used for the study.5ml of the ginger juice was administered orally for 21 days using the gavage oral tube to the experimental animals. Blood samples were collected via cardiac puncture after a chloroform anesthesia was given to the animals to a heparinized sample bottle. Plasma samples were analyzed for total cholesterol, triglyceride, high density lipoprotein using the colorimeter while and low-density lipoprotein level was calculated.
Results: There was no significant difference in cholesterol, triglyceride, high density lipoprotein and low-density lipoprotein levels (P>0.05) when the group 1(control group) was compared with group 2 (dry ginger group) and group 3 (fresh ginger group).
Conclusion: Ginger juice in different preparation forms does not alter the lipid profiling in the experimental animals over a period of 21 days.
Keywords: Dry ginger, Fresh ginger, ginger juice, lipid profile, albino rats
How to Cite
References
Vodnala D, Rubenfire M, Brook RD. Secondary causes of dyslipidemia. American Journal of Cardiology. 2012; 110(6):823-825.
Veerkemp MJ, De Graaf J, Den Heijer M, Blom HJ, Stalenhoef AF. Plasma homocysteine in subjects with familial combined hyperlipidemia. Artherosclerosis. 2003;166:111-117
Weissglas-Volkov D, Pajukanta P. Genetic causes of high and low serum HDL cholesterol.The Journal of Lipid Research. 2010;51:2032-2057.
Maqbool M, Dar MA, Gani I, Mir SA, Khan M. Herbal Medicines as an Alternative Source of Therapy: A Review. World Journal of Pharmacy and Pharmaceutical Sciences. 2012;8(2):374-380.
Bhandari U, Sharma JN, Zafar R. The protective action of ethanolic ginger (Zingiber Officinale) extract in cholesterol fed rabbits. Journal of Ethnopharmacology. 1998;61:167-171.
Ghayur MN, Gilani AH. Ginger lowers blood pressure through blockage of voltage- dependent calcium channels. Journal of Cardiovascular Pharmacology. 2005;45:74-80.
Ebrahimzadeh AX, Malex MA, Jaxadixala Z, Zununi VS, Ostradrahimi A. A systemic review of the anti-obesity and weight lowering effect of ginger and its mechanism of actions. Phytotherapy Research. 2018;32:577-585.
Moghaddasi MS, Kashani HH.Ginger (Zingiber officinale): A review. Journal of Medicinal Plants Research. 2012;6(26): 4255-4258,
Grzanna R, Lindmark L, Frondoza CG. Ginger an herbal medicinal product with broad anti-inflammatoryactions. Journal of Medicine and Food. 2005; 8125-132.
Britannica, The Editors of Encyclopaedia. "ginger". Encyclopedia Britannica; 2023.
Available:https://www.britannica.com/plant/ginger. Accessed 25 February 2023
Leech J. 11 proven Health Benefits of Ginger, Nutrition. 2021;1:1-34.
Pillai KK, Bhandari U, Kanojia R. Effect of ethanolic extract of Zingiber Officinale on dyslipiudaemia in rats, Journal of Ethnopharmacology. 2005;97:227-230.
Qian-Qian M, Xiao-Yu Xu, Sui-Yu C, Ren-You G, Harold Corke TB, Hua-Bin Li. Bioactive compounds and Bioactivities of ginger (Zingiber officinale Roscoe. Foods. 2019; 8(6):185-187.
Wang J, Ke W, Bao R, Hu X, Chen F. Beneficial effect of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome, A review. Annals of Academic Science. 2017;1398:83-98.
Rahmani AH, Aly SM. Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities. International Journal of Physiology, Pathophysiology & Pharmacology. 2014; 6(2): 125–136.
Shrin Adel PR, Prakash J. Chemical composition and qanti oxidant properties of ginger root. Journal of Medicinal plants and Reserves. 2010;4(24):2674-2679.
Al-Hassan YT Fabella EL Estrella E Aatif M. Prevalence and Determinants of Dyslipidemia: Data from a Saudi University Clinic.The Open Public Health Journal. 2018; 11: 416-424.
ILAR. Guideline for the care and use of laboratory animal.8th edition. National academic press. Washington D.C; 2011.
LAW. Institution Animal care and use committee Guidebook.2nd edition NIH publication; Bethesda. 2002.
Hoque MA, Bala BK Hossain MA Borhan Uddin M.Drying Kinetics of Ginger Rhizome (Zingiber officinale).Bangladesh Journal of Agricultural Research. 2013;38(2):301-319.
Eblen-Zajjur A Eblen-Zajjur M. Estimation of low density lipoprotein cholesterol concentration:regression analysis versus Friedwald’s formula. Revista Medica de Chile. 2001;129(11):1263-1270.
Prasad SS Sushil, K Vaspeyee SK Bhavsar VH. To establish the effect of ginger juice on important parameters of Lipid profile. International Journal of Pharmacology Sciences and Research.2012;3(4):352-357.
Thomson M, Al-Qattan KK, Al-Sawan SM , Alnaqeeb MA, Khan I, Ali M. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukotrienes and Essential Fatty Acids. 2002;67(6):475-478.
Li Y Hong Y Han Y Wang Y Xia L. Chemical characterization and anti- oxidant activities comparison in fresh, dried, stir-frying and carbonized ginger. Journal of Chromatography. 2016;1011: 223-232.
Cheng XL Lin Q Peng YB Qil W Li P. Steamed ginger (Zingiber officinale): changed chemical profile and increased anti-cancer potentials. Food Chemistry. 2011 129:1785-1792.
Ahmed RS Sharma SB. Biochemical studies on combined effects of garlic (Allium sativum Linn) and ginger (Zingiber officinale Rosc) in albino rats. Indian Journal of Experimental Biology. 1997; 35(8):841-843.
Gälman C Arvidsson I Angelin B Rudling M. Monitoring hepatic cholesterol 7-hydroxylase activity by assay of the stable bile acid intermediate 7-hydroxy-4-cholesten-3-one in peripheral blood. Journal of Lipid Reseach.2003;44:859- 866.
Pourmasoumi M, Hadi A, Rafie N, Najafgholizadeh A, Mohammadi H, Rouhani MH. The effect of ginger supplementation on lipid profile: A systematic review and meta-analysis of clinical trials. Phytomedicine. 2018;1(43): 28-36.
Murad S Niaz K Aslam H. Effects of Ginger on LDL-C, Total Cholesterol and Body Weight. Clinical and Medical Biochemistry. 2018;4(2):1-4.
Fakhri Z, Shab-Bidar S, Firoozi S, Djafarian K. The Effects of Ginger Supplementation on Lipid Profile: A Meta-Analysis of Randomized Clinical Trials. Herbal Medicine Journal. 2018;3(3):120-131.
Nicoll R, Henein MY. Ginger (Zingiber officinale Roscoe): A hot remedy for cardiovascular disease?,International Journal of Cardiology. 2009;131(3):408-409.